alpha(2) Adrenoceptor agonists as potential analgesic agents. 2. Discovery of 4-(4-Imidazo)-1,3-dimethyl-6,7-dihydrothianaphthene [corrected] as a high-affinity ligand for the alpha(2D) adrenergic receptor

J Med Chem. 2000 Mar 9;43(5):765-8. doi: 10.1021/jm990569e.

Authors

T M Ross¹, M C Jetter, M E McDonnell, R E Boyd, C D Connelly, R P Martinez, M A Lewis, E E Codd, R B Raffa, A B Reitz

Affiliation

¹ Drug Discovery Division, The R. W. Johnson Pharmaceutical Research Institute, Spring House, Pennsylvania 19477, USA.

PMID: 10715142
DOI: 10.1021/jm990569e

No abstract available

MeSH terms

Administration, Oral
Adrenergic alpha-2 Receptor Agonists*
Adrenergic alpha-Agonists / chemical synthesis*
Adrenergic alpha-Agonists / chemistry
Adrenergic alpha-Agonists / metabolism
Adrenergic alpha-Agonists / pharmacology
Analgesics, Non-Narcotic / chemical synthesis*
Analgesics, Non-Narcotic / chemistry
Analgesics, Non-Narcotic / metabolism
Analgesics, Non-Narcotic / pharmacology
Animals
Binding, Competitive
Cell Line
Imidazoles / chemical synthesis*
Imidazoles / chemistry
Imidazoles / metabolism
Imidazoles / pharmacology
In Vitro Techniques
Mice
Rats
Receptors, Adrenergic, alpha-2 / metabolism
Structure-Activity Relationship
Thiophenes / chemical synthesis*
Thiophenes / chemistry
Thiophenes / metabolism
Thiophenes / pharmacology

Substances

Adrenergic alpha-2 Receptor Agonists
Adrenergic alpha-Agonists
Analgesics, Non-Narcotic
Imidazoles
Receptors, Adrenergic, alpha-2
Thiophenes